Hydrogen Bromide → HCID 19595243, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2,3-dihydro-5-methoxy-N-(4-pyridinyl)-1 H-isoindol-2-amine (5.25 g) in 48% hydrobromic acid (35 ml) was heated under reflux for 5 hrs, with stirring. The reaction mixture was cooled to about 10° C. and filtered. The filter cake was washed with cold water and dried under vacuum in an oven at 80° C. to give 4.8 g (72%) of product. The product was recrystallized from water and dried under vacuum at 80° C. to give 3.1 g (46%) of the analytical sample, mp 261-264° C.

Provenance & Evidence