Hydrogen Bromide → HCID 19595243, compound

HRID 612463Notes

Reaction equation

HRID 612463 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([NH:12][C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[CH2:6]2.[BrH:19]>>[BrH:19].[N:16]1[CH:15]=[CH:14][C:13]([NH:12][N:7]2[CH2:6][C:5]3[C:9](=[CH:10][CH:11]=[C:3]([OH:2])[CH:4]=3)[CH2:8]2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19595139HCID 19595139, compound

Product 1

HCID 19595243HCID 19595243, compoundYield 72%

Conditions

Temperature
10 °C

Procedure

A solution of 2,3-dihydro-5-methoxy-N-(4-pyridinyl)-1 H-isoindol-2-amine (5.25 g) in 48% hydrobromic acid (35 ml) was heated under reflux for 5 hrs, with stirring. The reaction mixture was cooled to about 10° C. and filtered. The filter cake was washed with cold water and dried under vacuum in an oven at 80° C. to give 4.8 g (72%) of product. The product was recrystallized from water and dried under vacuum at 80° C. to give 3.1 g (46%) of the analytical sample, mp 261-264° C.

Workup

  1. temperatureunder reflux for 5 hrs
  2. filtrationfiltered
  3. washThe filter cake was washed with cold water
  4. customdried under vacuum in an oven at 80° C.

Sources & evidence

ORD record
ord-cc0cb014f334449f9c9748620d748bf2
Source dataset
uspto-grants-1999_12
Patent number
US06004977

Reaction notes

Loading…