反应详情

A solution of 2,3-dihydro-4-fluoro-5-methoxy-N-(4-pyridinyl)-1H-isoindol-2-amine (3.25 g) in 48% hydrobromic acid (25 ml) was stirred, under reflux, for 5 hrs. The reaction mixture was diluted with water and stirred at ambient temperature overnight. The mixture was cooled to approximately 10° C. and filtered. The filter cake was washed with cold water and dried under vacuum at 80° C. to give 2.8 g (69%) of product. Recrystallization from water gave the analytical sample, mp. >250° C., dried at 80° C. under vacuum.

1. temperatureunder reflux, for 5 hrs
2. temperatureThe mixture was cooled to approximately 10° C.
3. filtrationfiltered
4. washThe filter cake was washed with cold water
5. customdried under vacuum at 80° C.