2-Fluoro-5-(trifluoromethyl)pyrimidine → HCID 117727934, compound

HRID 61254Notes

Reaction equation

HRID 61254 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)=[C:7]([CH:11]=1)[C:8]([OH:10])=O)#[N:2].[CH3:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][NH:20][C@@H:19]1[CH2:24][N:25]1[C:33](=O)C2C(=CC=CC=2)C1=O.FC1[N:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[CH3:17][C@@H:18]1[CH2:23][CH2:22][CH2:21][N:20]([C:8]([C:7]2[CH:11]=[C:3]([CH:4]=[CH:5][C:6]=2[N:12]2[N:16]=[CH:15][CH:14]=[N:13]2)[C:1]#[N:2])=[O:10])[C@@H:19]1[CH2:24][NH:25][C:33]1[N:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1

Participants

4

Reactant 3

HCID 200718852-Fluoro-5-(trifluoromethyl)pyrimidineHCID 679825925-cyano-2-(2H-1,2,3-triazol-2-yl)benzoic acidHCID 1177276302-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

Product 1

HCID 117727934HCID 117727934, compound

Procedure

The title compound was prepared following the same general protocol as described in Example A1, using 5-cyano-2-(2H-1,2,3-triazol-2-yl)benzoic acid, 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione and 2-fluoro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 471 [M+1]+.

Sources & evidence

ORD record
ord-76309cdf7292464aa9da85d353630a3e
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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