2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 117728399, compound

HRID 61255Notes

Reaction equation

HRID 61255 reaction equation
C(C1C=CC(I)=C(C=1)C(O)=O)#N.[NH2:13][CH2:14][C@@H:15]1[C@H:20]([CH3:21])[CH2:19][CH2:18][CH2:17][N:16]1[C:22]([C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=1[C:32]1[N:37]=[CH:36][CH:35]=[CH:34][N:33]=1)[C:27]#[N:28])=[O:23].Cl[C:39]1[N:44]=[CH:43][C:42]([C:45]([F:48])([F:47])[F:46])=[CH:41][N:40]=1>>[CH3:21][C@@H:20]1[CH2:19][CH2:18][CH2:17][N:16]([C:22]([C:24]2[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=2[C:32]2[N:33]=[CH:34][CH:35]=[CH:36][N:37]=2)[C:27]#[N:28])=[O:23])[C@@H:15]1[CH2:14][NH:13][C:39]1[N:44]=[CH:43][C:42]([C:45]([F:48])([F:47])[F:46])=[CH:41][N:40]=1

Participants

4

Reactant 3

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 220088225-Cyano-2-iodobenzoic acidHCID 1177284853-((2S,3R)-2-(aminomethyl)-3-methylpiperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile

Product 1

HCID 117728399HCID 117728399, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A230 using 5-cyano-2-iodobenzoic acid to make 3-((2S,3R)-2-(aminomethyl)-3-methylpiperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile and 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 482 [M+1]+.

Sources & evidence

ORD record
ord-45f3f5c72fc94559923b72fbb80c4462
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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