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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 61255Generated: October 30, 2026

2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 117728399, compound

https://huagongshe.com/reaction/61255

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Chloro-5-(trifluoromethyl)pyrimidineHCID 13317019—
Reactant5-Cyano-2-iodobenzoic acidHCID 22008822—
Reactant3-((2S,3R)-2-(aminomethyl)-3-methylpiperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrileHCID 117728485—
ProductHCID 117728399HCID 117728399—

Reaction Steps

The title compound was prepared following the same general protocol as described for Example A230 using 5-cyano-2-iodobenzoic acid to make 3-((2S,3R)-2-(aminomethyl)-3-methylpiperidine-1-carbonyl)-4-(pyrimidin-2-yl)benzonitrile and 2-chloro-5-(trifluoromethyl)pyrimidine. ESI-MS (m/z): 482 [M+1]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09440982B2
Source datasetuspto-grants-2016_09
ORD IDord-45f3f5c72fc94559923b72fbb80c4462
Source noteuspto-grants-2016_09