2-Chloro-5-(trifluoromethyl)pyrimidine → HCID 117727714, compound

HRID 61265Notes

Reaction equation

HRID 61265 reaction equation
[CH3:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][NH:4][C@@H:3]1[CH2:8][N:9]1[C:17](=O)C2C(=CC=CC=2)C1=O.[CH3:20][C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=O)=[C:23]([C:30]2[N:35]=[CH:34][CH:33]=[CH:32][N:31]=2)[CH:22]=1.ClC1[N:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1>>[CH3:1][C@@H:2]1[CH2:7][CH2:6][CH2:5][N:4]([C:25]([C:24]2[CH:28]=[CH:29][C:21]([CH3:20])=[CH:22][C:23]=2[C:30]2[N:35]=[CH:34][CH:33]=[CH:32][N:31]=2)=[O:27])[C@@H:3]1[CH2:8][NH:9][C:17]1[N:42]=[CH:41][C:40]([C:43]([F:46])([F:45])[F:44])=[CH:39][N:38]=1

Participants

4

Reactant 3

HCID 133170192-Chloro-5-(trifluoromethyl)pyrimidineHCID 681666184-Methyl-2-(pyrimidin-2-yl)benzoic acidHCID 1177276302-(((2S,3R)-3-Methylpiperidin-2-yl)methyl)isoindoline-1,3-dione

Product 1

HCID 117727714HCID 117727714, compound

Procedure

The title compound was prepared following the same general protocol as described for Example A389 using 2-(((2S,3R)-3-methylpiperidin-2-yl)methyl)isoindoline-1,3-dione, 4-Methyl-2-(pyrimidin-2-yl)benzoic acid and 2-chloro-5-(trifluoromethyl)pyrimidine. 1H NMR (500 MHz, CD3OD) δ 9.00-6.70 (m, 8H), 5.15-2.85 (m, 5H), 2.45-0.65 (m, 11H); ESI MS (M+H) 471.

Sources & evidence

ORD record
ord-29de2b8b5fe54f48add890039b82f115
Source dataset
uspto-grants-2016_09
Patent number
US09440982B2

Reaction notes

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