反应详情

The solution of 4-(2-piperidinylethoxy)benzyl alcohol in ethylene dichloride can be combined with thionyl chloride and heated until the reaction is complete. Upon cooling, the mixture can be concentrated, followed by addition of 1,2-dimethoxyethane and additional concentration. The precipitate can be collected and dried to yield intermediate 4-(2-piperidinylethoxy)benzylchloride hydrochloride, as shown in Scheme IX. ##STR36##

1. temperatureheated until the reaction
2. temperatureUpon cooling
3. concentrationthe mixture can be concentrated
4. additionfollowed by addition of 1,2-dimethoxyethane and additional concentration
5. customThe precipitate can be collected
6. customdried