tert-butyl N-(2-hydroxyethyl)carbamate → HCID 19596585, compound

HRID 612861Notes

Reaction equation

HRID 612861 reaction equation
Cl[C:2]1[C:3]([OH:12])=[N:4][O:5][C:6]=1[C:7]1[S:8][CH:9]=[CH:10][CH:11]=1.[C:13]([O:17][C:18]([NH:20][CH2:21][CH2:22]O)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[C:13]([O:17][C:18]([NH:20][CH2:21][CH2:22][O:12][C:3]1[CH:2]=[C:6]([C:7]2[S:8][CH:9]=[CH:10][CH:11]=2)[O:5][N:4]=1)=[O:19])([CH3:16])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 2733206tert-butyl N-(2-hydroxyethyl)carbamateHCID 178519005HCID 178519005, compound

Product 1

HCID 19596585HCID 19596585, compoundYield 74.1%

Procedure

4-Chloro-3-hydroxy-5-(2-thienyl)isoxazole (0.50 g) and 2-(N-tert-butoxycarbonylamino)ethanol (0.40 g) were subjected to reaction and post-treatment in a similar manner to that described in Example 1(a) to obtain the title compound (0.57 g, 66%) as colorless crystals.

Sources & evidence

ORD record
ord-e452918cb91f49529da523ee82f28b43
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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