HCID 19596650, compound → HCID 19596632, compound

HRID 612865Notes

Reaction equation

HRID 612865 reaction equation
C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[O:14][N:13]=1)=O)(C)(C)C.[ClH:25].O1CCOCC1>>[ClH:25].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[O:23][CH3:24])[O:14][N:13]=1

Participants

3

Reactant 2

HCID 19596650HCID 19596650, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 19596632HCID 19596632, compoundYield 84%

Procedure

3-(2-(N-tert-Butoxycarbonylamino)ethoxy)-5-(2-methoxyphenyl)isoxazole (0.31 g) was dissolved in a solution of 4N hydrochloric acid/1,4-dioxane (2.3 ml), and the solution was stirred at room temperature for 30 minutes. The solvent was evaporated under reduced pressure and the residue was recrystallized from a mixture of ethanol and isopropanol to obtain the title compound (0.21 g, 84%) as colorless crystals.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from a mixture of ethanol and isopropanol

Sources & evidence

ORD record
ord-1ed9c36371bf446ba8592bb4cd2d875f
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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