Iodoethane → 3-(2-(N-tert-Butoxycarbonylamino)ethoxy)-4-ethyl-5-phenylisoxazole

HRID 612871Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:16]=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:23](I)[CH3:24]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]([CH2:23][CH3:24])=[C:15]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6340Iodoethane

HCID 154349603-(2-(N-tert-butoxycarbonylamino)ethoxy)-5-phenylisoxazole

Product 1

HCID 195965173-(2-(N-tert-Butoxycarbonylamino)ethoxy)-4-ethyl-5-phenylisoxazoleYield 73%

Procedure

3-(2-(N-tert-Butoxycarbonylamino)ethoxy)-5-phenylisoxazole (0.3 g) and ethyl iodide (0.12 ml) were subjected to reaction and post-treatment in a similar manner to that described in Example 14(a) to obtain the title compound (0.24 g, 73%) as a colorless oil.

Sources & evidence

ORD record: ord-d8d601eed303486391b7594529eff191
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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