Methylamine → HCID 19596513, compound

HRID 612877Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]([C:17](O)=[O:18])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:26][NH2:27]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]([C:17]([NH:27][CH3:26])=[O:18])=[C:15]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[O:14][N:13]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

Reactant 2

HCID 6329Methylamine

HCID 19596598HCID 19596598, compound

Product 1

HCID 19596513HCID 19596513, compoundYield 87%

Procedure

3-(2-(N-tert-Butoxycarbonylamino)ethoxy)-4-carboxy-5-phenylisoxazole (0.2 g) and methylamine (30% methanol solution, 0.12 ml) were subjected to reaction and post-treatment in a similar manner to that described in Example 20(a) to obtain the title compound (0.18 g, 87%) as a colorless powder.

Sources & evidence

ORD record: ord-9c826cda5d5b452d86a3db5fcfb8b867
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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