反应详情

温度

100 °C

Pyrrolidine (710 mg) was added to 3-(2-bromoethoxy)-5-phenylisoxazole (268 mg), and the mixture was stirred at 100° C. for one hour. After ice-cold water (20 ml) was added to the reaction mixture and the mixture was extracted with ether (20 ml×2), the organic layer was dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate) to obtain the title compound (211 mg, 82%) as colorless crystals.

1. extractionthe mixture was extracted with ether (20 ml×2)
2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
3. filtrationAfter filtration
4. customthe solvent was evaporated under reduced pressure
5. customThe residue was purified by silica gel column chromatography (eluent: ethyl acetate)