Hydroxyamine hydrochloride → HCID 178439784, compound

HRID 612945Notes

Reaction equation

C(OC(=O)C(C(=O)C1C=CC(Cl)=CC=1)C(C)C)C.[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[O:30][N:29]=[C:28]([OH:31])[C:27]=2[CH:32]([CH3:34])[CH3:33])=[CH:22][CH:21]=1.Cl.NO.C[O-].[Na+]>>[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([C:26]2[O:30][N:29]=[C:28]([OH:31])[C:27]=2[CH:32]([CH3:34])[CH3:33])=[CH:24][CH:25]=1

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 10942334Sodium Methoxide

HCID 178439785HCID 178439785, compound

Product 1

HCID 178439784HCID 178439784, compoundYield 131.9%

Procedure

5-(4-Chlorophenyl-3-hydroxy-4-isopropylisoxazole 2-(4-Chlorobenzoyl)isovaleric acid ethyl ester (2.1 g), hydroxylamine hydrochloride (1.1 g) and sodium methoxide (28% methanol solution, 7.5 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 8(b) to obtain the title compound (1.3 g, 71%) as colorless crystals.

Sources & evidence

ORD record: ord-3017d8a3f36346cc9336213e74b507e8
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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