Sodium Hydroxide → HCID 178515539, compound

HRID 612949Notes

Reaction equation

HRID 612949 reaction equation
C([O:3][C:4](=O)[C:5](Br)=[C:6](Br)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[C:13]([F:16])([F:15])[F:14])C.Cl.[NH2:21][OH:22].[OH-].[Na+]>>[OH:3][C:4]1[CH:5]=[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[C:13]([F:16])([F:15])[F:14])[O:22][N:21]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 443297Hydroxyamine hydrochlorideHCID 54512652HCID 54512652, compound

Product 1

HCID 178515539HCID 178515539, compoundYield 76%

Procedure

α,β-Dibromo-2-trifluoromethylcinnamic acid ethyl ester (17.9 g), hydroxylamine hydrochloride (3.8 g) and sodium hydroxide (9.1 g) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 10(c) to obtain the title compound (7.6 g, 76%) as colorless crystals.

Sources & evidence

ORD record
ord-b26ad590b21d4f7f913e101222a7ee3d
Source dataset
uspto-grants-1999_12
Patent number
US06005116

Reaction notes

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