Sodium Hydroxide → HCID 178515592, compound

HRID 612951Notes

Reaction equation

C([O:3][C:4](=O)[C:5](Br)=[C:6](Br)[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)C.Cl.[NH2:21][OH:22].[OH-].[Na+]>>[OH:3][C:4]1[CH:5]=[C:6]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[O:22][N:21]=1

Participants

Reactant 3

HCID 14798Sodium Hydroxide

HCID 443297Hydroxyamine hydrochloride

HCID 54144529HCID 54144529, compound

Product 1

HCID 178515592HCID 178515592, compoundYield 83%

Procedure

α,β-Dibromo-4-trifluoromethylcinnamic acid ethyl ester (17.9 g), hydroxylamine hydrochloride (3.8 g) and sodium hydroxide (9.1 g) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 10(c) to obtain the title compound (8.3 g, 83%) as colorless crystals.

Sources & evidence

ORD record: ord-cbdf220c49c049e98cf42188d179f8e0
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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