Sodium Hydroxide → HCID 178515512, compound

HRID 612959Notes

Reaction equation

C([O:3][C:4](=O)[C:5](Br)=[C:6]([C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)Br)C.Cl.[NH2:21][OH:22].[OH-].[Na+]>>[OH:3][C:4]1[CH:5]=[C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][CH:9]=2)[O:22][N:21]=1

Participants

Reactant 3

HCID 14798Sodium Hydroxide

HCID 443297Hydroxyamine hydrochloride

HCID 54408999HCID 54408999, compound

Product 1

HCID 178515512HCID 178515512, compoundYield 78.8%

Procedure

α,β-Dibromo-1-naphthylacrylic acid ethyl ester (6.0 g), hydroxylamine hydrochloride (1.3 g) and sodium hydroxide (7.2 g) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 10(c) to obtain the title compound (2.6 g, 78%) as colorless crystals.

Sources & evidence

ORD record: ord-1009afc05ee848c0a82d129920d16d80
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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