Hydroxyamine hydrochloride → HCID 178439787, compound

HRID 612962Notes

Reaction equation

C([O:3][C:4](=O)[CH:5]([C:9](=[O:18])[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][C:11]=1[F:17])[CH:6]([CH3:8])[CH3:7])C.Cl.[NH2:21]O.C[O-].[Na+]>>[F:17][C:11]1[CH:12]=[C:13]([F:16])[CH:14]=[CH:15][C:10]=1[C:9]1[O:18][N:21]=[C:4]([OH:3])[C:5]=1[CH:6]([CH3:8])[CH3:7]

Participants

Reactant 3

HCID 443297Hydroxyamine hydrochloride

HCID 10942334Sodium Methoxide

HCID 54415652HCID 54415652, compound

Product 1

HCID 178439787HCID 178439787, compoundYield 39.2%

Procedure

2-(2,4-Difluorobenzoyl)isovaleric acid ethyl ester (1.7 g), hydroxylamine hydrochloride (0.9 g) and sodium methoxide (28% methanol solution, 7.5 ml) were subjected to reaction and post-treatment in a similar manner to that described in Reference example 8(b) to obtain the title compound (0.59 g, 39%) as colorless crystals.

Sources & evidence

ORD record: ord-ab91e8a6d81e4e4a91d08ff4628d76d3
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06005116

Reaction notes

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