Hydrochloric Acid → HCID 19079193, compound

HRID 6130Notes

Reaction equation

HRID 6130 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][CH2:9][N:10]2[C:14](=[O:15])[C:13]3=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]3[C:11]2=[O:20])=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:21]>CO>[ClH:21].[NH2:1][C:2]1[C:7]([CH2:8][CH2:9][N:10]2[C:11](=[O:20])[C:12]3=[CH:19][CH:18]=[CH:17][CH:16]=[C:13]3[C:14]2=[O:15])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 152314972-Amino-3-(2-(phthalimido)ethyl]pyridine

Product 1

HCID 19079193HCID 19079193, compoundYield 79%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

In 5 ml of methanol was dissolved 237 mg (0.792 mmol) of 2-amino-3-[2-(phthalimido)ethyl]pyridine. The solution was treated with 5 ml (10 mmol) of a 2N solution of hydrogen chloride in methanol. The solvent was distilled off to obtain the desired powder. The powder thus obtained was washed with ether to obtain 233 mg of the desired compound (yield: 79.0%, pale yellow powder).

Workup

  1. distillationThe solvent was distilled off
  2. customto obtain the desired powder
  3. customThe powder thus obtained
  4. washwas washed with ether

Sources & evidence

ORD record
ord-6ab3399bbe384df4a016cb4e27a3ec16
Source dataset
uspto-grants-1993_09
Patent number
US05246948

Reaction notes

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