反应详情

温度

20 °C

Ethylenediamine (1.3 mL, 0.0194 mol, 100 mol %) was added to 2-methyl-2-(triphenylmethylthio)propanal (13.86 g, 0.0401 mol, 206 mol %) dissolved in methanol (40 mL) and anhydrous THF (40 mL) under argon, and the pH was adjusted to pH 6 by dropwise addition of acetic acid. The solution was stirred for 20 min at 20° C. Sodium cyanoborohydride (1.22 g, 0.0194 mol, 100 mol %) was added and the reaction was stirred at room temperature for 3 hours. Additional sodium cyanoborohydride (1.08 g) was added and the reaction was stirred at 20° C. for 17 hours. A final portion of sodium cyanoborohydride (1.02 g) was added and the reaction heated at reflux under argon for 6 hours. The reaction was quenched with 0.5 M HCl (100 mL) and extracted with ethyl acetate (2×100 mL). The organic extracts were combined, sequentially washed with 2 M NaOH (60 mL), saturated NaCl solution (60 mL), dried (Na2SO4), and filtered. The solvent was removed under reduced pressure to give 16.67 g of crude product which was crystallized from toluene/hexanes to afford 10.20 g (73% yield) of white crystals of the title compound. The melting point of the resulting compound was determined to be 83-86° C. FABMS analysis yielded an m/z of 721 (MH+). Nuclear magnetic resonance characterization experiments yielded the following molecular signature:

1. stirringthe reaction was stirred at room temperature for 3 hours
2. stirringthe reaction was stirred at 20° C. for 17 hours
3. temperaturethe reaction heated
4. temperatureat reflux under argon for 6 hours
5. customThe reaction was quenched with 0.5 M HCl (100 mL)
6. extractionextracted with ethyl acetate (2×100 mL)
7. washsequentially washed with 2 M NaOH (60 mL), saturated NaCl solution (60 mL)
8. dry with materialdried (Na2SO4)
9. filtrationfiltered
10. customThe solvent was removed under reduced pressure
11. customto give 16.67 g of crude product which
12. customwas crystallized from toluene/hexanes