Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester
Reaction equation
[N:1]1[CH:6]=[C:5]([C:7]([O-])=[O:8])[CH:4]=[CH:3][C:2]=1[C:10]([O:12][CH3:13])=[O:11].S(Cl)([Cl:16])=O>>[C:10]([C:2]1[CH:3]=[CH:4][C:5]([C:7]([Cl:16])=[O:8])=[CH:6][N:1]=1)([O:12][CH3:13])=[O:11]Participants
3
Procedure
In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester (6) (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride (7).
Sources & evidence
- ORD record
- ord-24bca99853f84752b486981efbe5424f
- Source dataset
- uspto-grants-1999_12
- Patent number
- US06008196
Reaction notes
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