HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2,5-Pyridinedicarboxylic acid, 2-methyl ester | HCID 42556131 | — |
| Product | 5-Chlorocarbonyl-pyridine-2-carboxylic acid methyl ester | HCID 15121177 | — |
Reaction Steps
In step a, the carboxylic acid functionality of the appropriate 2,5-pyridinedicarboxylic acid, 2-methyl ester (6) (Nippon Kagaku Zasshi, 1967, 88, 563) is converted to its acid chloride using techniques and procedures well known and appreciated by one of ordinary skill in the art, such as thionyl chloride, to give the corresponding 6-carbomethoxynicotinoyl chloride (7).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008196 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-24bca99853f84752b486981efbe5424f |
| Source note | uspto-grants-1999_12 |