Hydrogen Bromide → HCID 131721531, compound

HRID 613260Notes

Reaction equation

HRID 613260 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:19])[CH:7]1[CH2:16][CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:17]C)=[CH:12][CH:13]=2)[CH2:8]1.[BrH:20]>>[BrH:20].[BrH:20].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]([CH3:19])[CH:7]1[CH2:16][CH2:15][C:14]2[C:9](=[CH:10][C:11]([OH:17])=[CH:12][CH:13]=2)[CH2:8]1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 19592124HCID 19592124, compound

Product 1

HCID 131721531HCID 131721531, compoundYield 100%

Procedure

A mixture of N-(4-aminobutyl)-7-methoxy-2-(R,S)-methylamino-1,2,3,4-tetrahydronaphthalene (0.79 g, 3.0 mmol) and aqueous HBr (48%; 20 ml) was heated at reflux for 5 h, then evaporated in vacuo to give the title compound (1.2 g, 100%).

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 5 h
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-49d78ad3dade44d18af38ce15f672d46
Source dataset
uspto-grants-1999_12
Patent number
US06008219

Reaction notes

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