反应详情

2-Nitro-4-methoxybenzoic acid (43.4 g, 0.22 mol) in DMF (250 ml) was hydrogenated at 55 psi in the presence of 10% palladium on carbon (5.8 g) for 2.5 hours. The reaction mixture was filtered through SUPERCELL®, the filter cake was rinsed with ethanol and then the filtrate was poured into ice/water (3.5 L). A precipitate formed which was collected by filtration, washed with water and dried in an oven at 60° C. to afford 30.7 g (84%) of 4-methoxyanthranilic acid, m.p. 176-178° C. (dec.).

1. filtrationThe reaction mixture was filtered through SUPERCELL®
2. washthe filter cake was rinsed with ethanol
3. additionthe filtrate was poured into ice/water (3.5 L)
4. customA precipitate formed which
5. filtrationwas collected by filtration
6. washwashed with water
7. customdried in an oven at 60° C.