化工社化工社 化学情報印刷レポート · 研究参考用
Hydrochloric Acid → Ethyl 4-hydroxyphenylglycine, hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | N-(4-Hydroxyphenyl)glycine | HCID 67149 | — |
| 生成物 | Ethyl 4-hydroxyphenylglycine, hydrochloride | HCID 131720465 | 70% |
反応手順
To a suspension of 4-hydroxyphenylglycine (18.00 g, 0.11 mol) in EtOH (100 mL) was added 20% ethanolic HCl (30 mL). The mixture was heated at reflux for 14 h, then was allowed to cool and was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, and the organic extract was concentrated in vacuo to afford the title compound (15.00 g, 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06008235 |
| 出典データセット | uspto-grants-1999_12 |
| ORD ID | ord-83169680b8704fdea48d4c3c0732106c |
| 出典メモ | uspto-grants-1999_12 |