反应详情

To a suspension of 4-hydroxyphenylglycine (18.00 g, 0.11 mol) in EtOH (100 mL) was added 20% ethanolic HCl (30 mL). The mixture was heated at reflux for 14 h, then was allowed to cool and was concentrated under reduced pressure. The residue was partitioned between saturated aqueous NaHCO3 and EtOAc, and the organic extract was concentrated in vacuo to afford the title compound (15.00 g, 70%).

1. temperatureThe mixture was heated
2. temperatureat reflux for 14 h
3. temperatureto cool
4. concentrationwas concentrated under reduced pressure
5. customThe residue was partitioned between saturated aqueous NaHCO3 and EtOAc
6. extractionthe organic extract
7. concentrationwas concentrated in vacuo