Methyl iodide → HCID 19593119, compound

HRID 613397Notes

Reaction equation

HRID 613397 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([OH:24])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([F:17])([F:16])[S:11][CH2:12][CH2:13][O:14]C.F[C:26]1C=C(F)C=C[C:27]=1C(O)(CN1C=NC=N1)C(F)(F)SCCO.CI.C(I)C>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([O:24][CH2:26][CH3:27])([CH2:18][N:19]1[CH:23]=[N:22][CH:21]=[N:20]1)[C:10]([S:11][CH2:12][CH2:13][OH:14])([F:17])[F:16]

Participants

5

Reactant 4

HCID 6328Methyl iodideHCID 6340IodoethaneHCID 10665616HCID 10665616, compoundHCID 15433416HCID 15433416, compound

Product 1

HCID 19593119HCID 19593119, compound

Procedure

In a similar manner to Example 1 except that 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-methoxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol was replaced with 2-(2,4-difluorophenyl)-1,1-difluoro-1-[(2-hydroxyethyl)thio]-3-(1H-1,2,4-triazol-1-yl)-2-propanol and methyl iodide was replaced with ethyl iodide, the experiment was carried out, whereby 2-{[2-(2,4-difluorophenyl)-2-ethoxy-1,1-difluoro-3-(1H-1,2,4-triazol-1-yl)propyl]thio}-1-ethanol was obtained as a colorless oil.

Sources & evidence

ORD record
ord-0b2bea4cdd2e46ada183b49b4a32048b
Source dataset
uspto-grants-1999_12
Patent number
US06008239

Reaction notes

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