反应详情

A solution of 4-(4'-methylphenoxy)benzaldehyde (9.00 g, 41.63 mmol) in CHCl3 (75 mL) was treated with m-chloroperbenzoic acid (46-85%, 15.80 g, 52.00 mmol) and stirred for 3 h at room temperature. The reaction was washed with sat. aq. NaHSO3, sat. aq. NaHCO3, and water. The organic layer is concentrated and the residual oil taken up in MeOH (10 mL) containing a few drops of conc. HCL and stirred for 1 h at room temperature. The solvent is removed in vacuo and the resulting oil was chromatographed on silica gel (20% ethyl acetate/hexane) to afford 4-(4'-methylphenoxy)phenol.

1. washThe reaction was washed with sat. aq. NaHSO3, sat. aq. NaHCO3, and water
2. concentrationThe organic layer is concentrated
3. additioncontaining a few drops of conc. HCL
4. stirringstirred for 1 h at room temperature
5. customThe solvent is removed in vacuo
6. customthe resulting oil was chromatographed on silica gel (20% ethyl acetate/hexane)