HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl carbazate → 2-tert-butoxycarbonyl-2,3-dihydro-6-nitro-1H-pyrazolo[4,3-c]quinolin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl carbazate | HCID 70091 | — |
| Reactant | Ethyl 4-chloro-8-nitroquinoline-3-carboxylate | HCID 11196760 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-tert-butoxycarbonyl-2,3-dihydro-6-nitro-1H-pyrazolo[4,3-c]quinolin-3-one | HCID 19593009 | 77.8% |
Reaction Steps
A mixture of 4-chloro-3-ethoxycarbonyl-8-nitroquinoline (500 mg) and tert-butoxycarbonylhydrazine (283 mg) in dioxane was refluxed for 1 hour. The mixture was concentrated in vacuo to give 2-tert-butoxycarbonyl-2,3-dihydro-6-nitro-1H-pyrazolo[4,3-c]quinolin-3-one (458 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-a024566ab13248299f0b48d845e13f21 |
| Source note | uspto-grants-1999_12 |