反应详情

温度

60 °C

A mixture of 8-(2,6-dichlorobenzoylamino)-3-methylquinoline (104 mg), N-bromosuccinimide (67.1 mg) and 2,2'-azobis(2,4-dimethyl-4-methoxyvaleronitrile) (20.1 mg) in carbon tetrachloride (3 ml) was refluxed for 2 hours. After cooling, the mixture was washed with water, saturated sodium bicarbonate solution and brine, dried over magnesium sulfate and evaporated in vacuo to give a residue containing 3-bromomethyl-8-(2,6-dichlorobenzoylamino)quinoline. The residue was dissolved in ethylene chloride, and imidazole (64.1 mg) was added thereto. After stirring for 2.5 hours at 60° C., the mixture was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was purified by column chromatography on silica gel (ethyl acetate-dichloromethane) to give 8-(2,6-dichlorobenzoylamino)-3-(imidazol-1-ylmethyl)quinoline (36.2 mg).

1. temperaturewas refluxed for 2 hours
2. temperatureAfter cooling
3. washthe mixture was washed with water, saturated sodium bicarbonate solution and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customto give a residue
7. washthe mixture was washed with water and brine
8. dry with materialdried over magnesium sulfate
9. customevaporated in vacuo
10. customThe residue was purified by column chromatography on silica gel (ethyl acetate-dichloromethane)