Sodium Hydroxide → HCID 19592865, compound

HRID 613503Notes

Reaction equation

HRID 613503 reaction equation
[Cl:1][C:2]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][N:13]=[C:12]2[CH2:17]C(OCC)=O)=[O:5].[OH-].[Na+]>C(O)C.O>[Cl:27][C:23]1[CH:24]=[CH:25][CH:26]=[C:2]([Cl:1])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][N:13]=[C:12]2[CH3:17])=[O:5]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 19592651HCID 19592651, compound

Product 1

HCID 19592865HCID 19592865, compoundYield 94.7%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

A mixture of 8-(2,6-dichlorobenzoylamino)-4-ethoxycarbonylmethylquinazoline (90 mg) and 1N sodium hydroxide solution (1 ml) in ethanol (5 ml) was refluxed for 30 minutes. The mixture was diluted with water, and the resulting precipitate was collected by filtration and washed with water to give 8-(2,6-dichlorobenzoylamino)-4-methylquinazoline (70 mg).

Workup

  1. temperaturewas refluxed for 30 minutes
  2. filtrationthe resulting precipitate was collected by filtration
  3. washwashed with water

Sources & evidence

ORD record
ord-d6311e6619ea46f9b9dfb337b323426a
Source dataset
uspto-grants-1999_12
Patent number
US06008230

Reaction notes

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