Methanol → HCID 19592776, compound

HRID 613537Notes

Reaction equation

HRID 613537 reaction equation
Cl[CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[C:7]([N+:14]([O-:16])=[O:15])[CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1.[CH3:17][OH:18]>ClCCl>[CH3:17][O:18][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[C:7]([N+:14]([O-:16])=[O:15])[CH:8]=[CH:9][CH:10]=2)[NH:5][CH:4]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 19592334HCID 19592334, compound

Product 1

HCID 19592776HCID 19592776, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A suspension of 3-chloromethyl-1,4-dihydro-8-nitro-4-oxoquinoline (2 g) in dichloromethane (70 ml) and methanol (30 ml) was refluxed for 15 minutes and concentrated in vacuo. The crystalline residue was suspended in hot methanol (30 ml), and the mixture was allowed to stand to ambient temperature. The resulting precipitates were collected by filtration to give 1,4-dihydro-3-methoxymethyl-8-nitro-4-oxoquinoline (1.5 g).

Workup

  1. temperaturewas refluxed for 15 minutes
  2. concentrationconcentrated in vacuo
  3. customto stand to ambient temperature
  4. customThe resulting precipitates
  5. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-b615299f2b0149d38a333025592f3089
Source dataset
uspto-grants-1999_12
Patent number
US06008230

Reaction notes

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