Imidazole → HCID 178521896, compound

HRID 613544Notes

Reaction equation

HRID 613544 reaction equation
[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[N:15]=[CH:14][N:13]=[C:12]2[O:17]C(=O)C1C(Cl)=CC=CC=1Cl)=[O:5].N1C=CN=C1.O>CN1CCN(C)C1=O>[Cl:1][C:2]1[CH:31]=[CH:30][CH:29]=[C:28]([Cl:32])[C:3]=1[C:4]([NH:6][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]2[C:16]=1[NH:15][CH:14]=[N:13][C:12]2=[O:17])=[O:5]

Participants

5

Reactant 3

HCID 795ImidazoleHCID 962WaterHCID 19592577HCID 19592577, compound

Product 1

HCID 178521896HCID 178521896, compoundYield 87.3%

Reagents, catalysts & solvents 1

HCID 66611,3-Dimethyl-2-imidazolidinoneSolvent

Procedure

A mixture of 8-(2,6-dichlorobenzoylamino)-4-(2,6-dichlorobenzoyloxy)quinazoline (40 mg) and imidazole (53.7 mg) in 1,3-dimethyl-2-imidazolidinone (0.6 ml) was stirred for 1 hour at ambient temperature. Cold water was added to the mixture, and the resulting precipitates were collected by filtration to give 8-(2,6-dichlorobenzoylamino)-1,4-dihydro-4-oxoquinazoline (23 mg).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-cda07352503b4f91a6a265b693a97eae
Source dataset
uspto-grants-1999_12
Patent number
US06008230

Reaction notes

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