HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → 8-(2,6-Dichlorobenzoylamino)-4-[4-(methyl)thiosemicarbazido]quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | HCID 19592850 | HCID 19592850 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 8-(2,6-Dichlorobenzoylamino)-4-[4-(methyl)thiosemicarbazido]quinoline | HCID 19592937 | 88% |
Reaction Steps
A suspension of 8-(2,6-dichlorobenzoylamino)-4-hydrazinoquinoline (200 mg) and methyl isothiocyanate (54.8 mg) in ethylene chloride (4 ml) was stirred for 2 hours at ambient temperature and then gently refluxed for 24 hours. The mixture was concentrated in vacuo, and the residue was recrystallized from ethanol to give 8-(2,6-dichlorobenzoylamino)-4-[4-(methyl)thiosemicarbazido]quinoline (213 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06008230 |
| Source dataset | uspto-grants-1999_12 |
| ORD ID | ord-14cfc9eb5cbd40ebad3461f9301accd1 |
| Source note | uspto-grants-1999_12 |