反应详情

A suspension of 8-(2,6-dichlorobenzoylamino)-4-hydrazinoquinoline (200 mg) and methyl isothiocyanate (54.8 mg) in ethylene chloride (4 ml) was stirred for 2 hours at ambient temperature and then gently refluxed for 24 hours. The mixture was concentrated in vacuo, and the residue was recrystallized from ethanol to give 8-(2,6-dichlorobenzoylamino)-4-[4-(methyl)thiosemicarbazido]quinoline (213 mg).

1. temperaturegently refluxed for 24 hours
2. concentrationThe mixture was concentrated in vacuo
3. customthe residue was recrystallized from ethanol