Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 19592490 | HCID 19592490 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 19592706 | HCID 19592706 | 87.7% |
Reaction Steps
To a solution of 4-chloro-8-(2,6-dichlorobenzoylamino)-3-cyanoquinoline (300 mg) in N-methylpyrrolidone (6 ml) was dropwise added hydrazine monohydrate (399 mg), and the mixture was stirred for 2 hours at 90° C. Water (15 ml) was added thereto, the resulting precipitates were collected by filtration to give 3-amino-6-(2,6-dichlorobenzoylamino)-1H-pyrazolo[4,3-c]quinoline (260 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06008230 |
|---|
| Source dataset | uspto-grants-1999_12 |
|---|
| ORD ID | ord-3e8dc47371334364adcb45cf229f0fe8 |
|---|
| Source note | uspto-grants-1999_12 |
|---|
