Water → HCID 19592706, compound

HRID 613560Notes

Reaction equation

Cl[C:2]1[C:11]2[C:6](=[C:7]([NH:12][C:13](=O)[C:14]3[C:19]([Cl:20])=[CH:18][CH:17]=[CH:16][C:15]=3[Cl:21])[CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:23]#[N:24].[OH2:25].[NH2:26][NH2:27].O>CN1CCCC1=O>[NH2:24][C:23]1[C:3]2[CH:4]=[N:5][C:6]3[C:7]([NH:12][C:13](=[O:25])[C:14]4[C:15]([Cl:21])=[CH:16][CH:17]=[CH:18][C:19]=4[Cl:20])=[CH:8][CH:9]=[CH:10][C:11]=3[C:2]=2[NH:27][N:26]=1

Participants

Conditions

Temperature: 90 °C

Procedure

To a solution of 4-chloro-8-(2,6-dichlorobenzoylamino)-3-cyanoquinoline (300 mg) in N-methylpyrrolidone (6 ml) was dropwise added hydrazine monohydrate (399 mg), and the mixture was stirred for 2 hours at 90° C. Water (15 ml) was added thereto, the resulting precipitates were collected by filtration to give 3-amino-6-(2,6-dichlorobenzoylamino)-1H-pyrazolo[4,3-c]quinoline (260 mg).

Workup

customthe resulting precipitates
filtrationwere collected by filtration

Sources & evidence

ORD record: ord-3e8dc47371334364adcb45cf229f0fe8
Source dataset: uspto-grants-1999_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06008230

Reaction notes

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