反应详情

温度

2 °C

An aqueous solution of 153.2 mmol of D-phenylalanine methyl ester and 4.6 mmol of L-phenylalanine methyl ester (D/L ratio=97.1/2.9) and 335 mmol of HCl in 400 ml of pure water was neutralized to pH 3 with a 20% NaOH aqueous solution and concentrated to a weight of 100 g by means of a rotary evaporator. The concentrate was cooled to about 2° C., and the precipitated crystals were collected by filtration by suction. There was obtained 120.7 mmol of D-phenylalanine methyl ester hydrochloride having an optical purity of 99.97% as measured by HPLC.

1. concentrationconcentrated to a weight of 100 g by means of a rotary evaporator
2. filtrationthe precipitated crystals were collected by filtration by suction