反应详情

In 40 ml of dimethylformamide was dissolved 1.82 g of 2-amino-6-ethyl-4-oxo-4H-1-benzopyran-3-carboxaldehyde, followed by the addition of 3.5 g of cyanoacetyl chloride. The mixture was reacted at 60° C. for 3 hours, with constant stirring. The solvent was then distilled off under reduced pressure and the residue was chromatographed on silica gel. The desired product was recovered from the chloroform eluate and recrystallized from acetonitrile. By the above procedure was obtained 1.03 g of 7-ethyl-3-cyano-1-azaxanthone, m.p. 183°-185° C.

1. customThe mixture was reacted at 60° C. for 3 hours, with constant stirring
2. distillationThe solvent was then distilled off under reduced pressure
3. customthe residue was chromatographed on silica gel
4. customThe desired product was recovered from the chloroform eluate
5. customrecrystallized from acetonitrile