Hydrogen Bromide → HCID 21329805, compound

HRID 614012Notes

Reaction equation

HRID 614012 reaction equation
Br.Cl.C[O:4][C:5]1[CH:6]=[C:7]2[O:11][CH:10]([CH3:12])[CH2:9][C:8]2=[C:13]([NH:15][CH3:16])[CH:14]=1>C(O)(=O)C>[OH:4][C:5]1[CH:6]=[C:7]2[O:11][CH:10]([CH3:12])[CH2:9][C:8]2=[C:13]([NH:15][CH3:16])[CH:14]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21329800HCID 21329800, compound

Product 1

HCID 21329805HCID 21329805, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5 cc of 48% HBr are added to a solution of 5 grams of 2,3-dihydro-6-methoxy-N,2-dimethyl-4-benzofuranamine hydrochloride in 20 cc of acetic acid and the resulting mixture is refluxed for 16 hours. At the end of this time the solvent is evaporated off and the residue, taken up with sodium bicarbonate, is thoroughly extracted with ether. Evaporation of this organic phase, previously dried over Na2SO4, gives a crude residue which crystallized from ethyl ether-petroleum ether yields 3 grams of the desired end product. Yield 77 percent of theoretical. M.p. 126°-128° C.

Workup

  1. temperaturethe resulting mixture is refluxed for 16 hours
  2. customAt the end of this time the solvent is evaporated off
  3. extractionis thoroughly extracted with ether
  4. customEvaporation of this organic phase
  5. dry with materialpreviously dried over Na2SO4

Sources & evidence

ORD record
ord-50892475ea2545f38edf7dfea674ba98
Source dataset
uspto-grants-1979_03
Patent number
US04143055

Reaction notes

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