反应详情

A solution of 3.9 g of p-chloro-α,α-dimethylbenzyl isocyanate, prepared from the corresponding cyanide in the same way as in Synthesis Example 1, in 20 ml of toluene was added to 2.7 g of N-ethylaniline and the mixture was heated under reflux for 3 hours. After allowing the reaction mixture to cool, the mixture was washed successively with 2N hydrochloric acid, 2N aqueous sodium hydroxide and water. The organic layer was dried over anhydrous sulfate and the solvent was removed by distillation under reduced pressure to obtain 6.2 g of the title compound as a light brown oily substance.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 3 hours
3. temperatureto cool
4. washthe mixture was washed successively with 2N hydrochloric acid, 2N aqueous sodium hydroxide and water
5. dry with materialThe organic layer was dried over anhydrous sulfate
6. customthe solvent was removed by distillation under reduced pressure