N-Ethyl cyclohexylamine → HCID 21329852, compound

HRID 614027Notes

Reaction equation

HRID 614027 reaction equation
[F:1][C:2]1[CH:13]=[CH:12][C:5]([C:6]([N:9]=[C:10]=[O:11])([CH3:8])[CH3:7])=[CH:4][CH:3]=1.[CH2:14]([NH:16][CH:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1)[CH3:15]>CCCCCC>[CH:17]1([N:16]([CH2:14][CH3:15])[C:10]([NH:9][C:6]([CH3:8])([CH3:7])[C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:13][CH:12]=2)=[O:11])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 21609N-Ethyl cyclohexylamineHCID 21329848HCID 21329848, compound

Product 1

HCID 21329852HCID 21329852, compoundYield 87.7%

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

A solution of 1.8 g of p-fluoro-α,α-dimethylbenzyl isocyanate in 20 ml of n-hexane was added to 1.4 g of N-ethylcyclohexylamine, and the mixture was allowed to stand overnight. The solvent was then removed by distillation and the resulting crystals were washed with cold n-pentane to obtain 2.7 g of the title compound.

Workup

  1. customThe solvent was then removed by distillation
  2. washthe resulting crystals were washed with cold n-pentane

Sources & evidence

ORD record
ord-ec1af4fb194243a49ed15e7dd2ee8549
Source dataset
uspto-grants-1979_03
Patent number
US04143061

Reaction notes

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