HCID 21330005, compound → HCID 21330002, compound

HRID 614065Notes

Reaction equation

HRID 614065 reaction equation
C([NH:11][CH:12]([C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[CH2:17][CH2:16][N:15]=1)[CH3:13])(OCC1C=CC=CC=1)=O.[BrH:28].C(O)(=O)C>>[BrH:28].[BrH:28].[NH2:11][CH:12]([C:14]1[C:23]2[C:18](=[CH:19][C:20]([O:26][CH3:27])=[C:21]([O:24][CH3:25])[CH:22]=2)[CH2:17][CH2:16][N:15]=1)[CH3:13]

Participants

3

Reactant 2

HCID 21330005HCID 21330005, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 21330002HCID 21330002, compound

Procedure

40 g 1-(1-carbobenzoxyaminoethyl)-3,4-dihydro-6,7-dimethoxyisoquinoline are dissolved in 450 ml 40% HBr/acetic acid. The mixture is maintained at room temperature for 1 hour and then concentrated in a vacuum to give a crystalline residue of 1-(1-aminoethyl)-3,4-dihydro-6,7-dimethoxyisoquinoline dihydrobromide which is washed with ether before further use (M.Pt. 234°-235°).

Workup

  1. concentrationconcentrated in a vacuum

Sources & evidence

ORD record
ord-ab217360f72044cd84b88f326ff6e7ac
Source dataset
uspto-grants-1979_03
Patent number
US04143143

Reaction notes

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