反应详情

A solution was prepared by dissolving 5.28 grams (0.11 mole) of sodium hydride (as a 50 percent oil mixture) in 15.20 grams (0.11 mole) of 2-phenoxyethanol. To this solution was added, over a 30 minute period, 26.54 grams (0.1 mole) of 2,6-dichloro-4-(trichloromethyl)pyridine. The mixture was heated and refluxed for 4 hours. The reaction mixture was diluted with 700 ml of water and extracted with methylene chloride. The extract was washed with water, dried with sodium sulfate and filtered. The methylene chloride and other volatile impurities were removed by distillation under reduced pressure. The 2-chloro-6-(2-phenoxyethoxy)-4-(trichloromethyl)pyridine product which was recovered distilled at 95° C. under0.05 mm of pressure. The product was recovered in a yield of 27 grams (73.5 percent of theoretical). The product solidified upon standing at 60°-62° C. Upon analysis, the product was found to have carbon, hydrogen, nitrogen, and chlorine contents of 46.22, 3.15, 3.94 and 37.92 percent, respectively, as compared with the theoretical contents of 45.81, 3.02, 3.82 and 38.64 percent, respectively, calculated for the above named compound.

1. customA solution was prepared
2. additionTo this solution was added, over a 30 minute period
3. temperatureThe mixture was heated
4. temperaturerefluxed for 4 hours
5. extractionextracted with methylene chloride
6. washThe extract was washed with water
7. dry with materialdried with sodium sulfate
8. filtrationfiltered
9. customThe methylene chloride and other volatile impurities were removed by distillation under reduced pressure
10. customThe 2-chloro-6-(2-phenoxyethoxy)-4-(trichloromethyl)pyridine product which was recovered
11. distillationdistilled at 95° C. under0.05 mm of pressure
12. customThe product was recovered in a yield of 27 grams (73.5 percent of theoretical)
13. customupon standing at 60°-62° C