Sodium Hydroxide → HCID 86736375, compound

HRID 614083Notes

Reaction equation

Cl.[CH:2]1([N:8]2[CH2:12][CH2:11][CH:10]([NH:13][C:14]([C:16]3[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=3[NH:18][C:19](=[O:25])[C:20]([O:22]CC)=[O:21])=[O:15])[CH2:9]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[OH-].[Na+:31]>C(O)C>[CH:2]1([N:8]2[CH2:12][CH2:11][CH:10]([NH:13][C:14]([C:16]3[CH:29]=[CH:28][CH:27]=[CH:26][C:17]=3[NH:18][C:19](=[O:25])[C:20]([O-:22])=[O:21])=[O:15])[CH2:9]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[Na+:31]

Participants

Conditions

Temperature: 50 °C

Procedure

A stirred solution of 4.2 g. of ethyl 2-(1-cyclohexyl-3-pyrrolidinylaminocarbonyl)oxanilate hydrochloride in 20 ml. of 50% aqueous ethanol was treated dropwise with 19.5 ml. of 1.03 N sodium hydroxide. After thirty minutes the solution was heated to 50° C. and poured into 130 ml. of boiling ethanol. After the mixture cooled to room temperature it was kept at 4° C. for two days and the amorphous sodium salt was collected by filtration.

Workup

additionpoured into 130 ml
temperatureAfter the mixture cooled to room temperature it
filtrationthe amorphous sodium salt was collected by filtration

Sources & evidence

ORD record: ord-286874251c9641f0a13486fe382fc785
Source dataset: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04143150

Reaction notes

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