Ethyl Lactate → 2-hydroxy-N-propyl-propanamide

HRID 614085Notes

Reaction equation

[C:1]([O:6]CC)(=O)[CH:2]([CH3:4])[OH:3].[CH2:9]([NH2:12])[CH2:10][CH3:11]>>[CH2:9]([NH:12][C:1](=[O:6])[CH:2]([CH3:4])[OH:3])[CH2:10][CH3:11]

Participants

Reactant 2

HCID 7344Ethyl Lactate

HCID 7852Propylamine

Product 1

HCID 102408342-hydroxy-N-propyl-propanamideYield 76.2%

Conditions

Temperature: 60 °C

Procedure

A mixture of 35.4 gm (0.3 mole) of ethyl lactate and 19.4 gm (0.33 mole) of propylamine were stirred together at 60° C. for 16 hours and subsequently distilled under reduced pressure. 30 gm (76% of theory) of N-propyl-lactic acid amide of boiling point 152° C./9 torr and of refractive index (nD20) 1.4563 were obtained.

Workup

distillationsubsequently distilled under reduced pressure

Sources & evidence

ORD record: ord-d9444ae3fdf944e38538cc317f3b8821
Source dataset: uspto-grants-1979_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04143159

Reaction notes

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