反应详情

An 8.8 g. portion of 4-ethoxy-3-thiophenecarbonyl chloride is dissolved in 100 ml. of methylene chloride and added dropwise to a mixture of 6.6 g. of 5-chloro-2-hydroxyaniline in 100 ml. of methylene chloride and 6.5 ml. of triethylamine. This mixture is stirred at ambient temperature overnight, concentrated to 100 ml. and filtered. The filtrate is allowed to stand overnight and the precipitate which forms is collected, washed with water and dried in vacuo. This combined precipitate is recrystallized from 200 ml. of ethanol, treated with charcoal, filtered through diatomaceous earth and concentrated giving 5'-chloro-4-ethoxy-2'-hydroxy-3-thiophenecarboxanilide as red brown crystals.

1. concentrationconcentrated to 100 ml
2. filtrationand filtered
3. waitto stand overnight
4. customthe precipitate which forms is collected
5. washwashed with water
6. customdried in vacuo
7. customThis combined precipitate is recrystallized from 200 ml
8. additionof ethanol, treated with charcoal
9. filtrationfiltered through diatomaceous earth
10. concentrationconcentrated