1-Methylpiperazine → HCID 12703434, compound

HRID 614216Notes

Reaction equation

HRID 614216 reaction equation
Cl[C:2]1[C:3]2[C:4](=[CH:13][S:14][CH:15]=2)[S:5][C:6]2[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=2[N:8]=1.[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.[C:23]([O-:30])(=[O:29])/[CH:24]=[CH:25]/[C:26]([O-:28])=[O:27]>C1(C)C=CC=CC=1>[C:23]([OH:30])(=[O:29])/[CH:24]=[CH:25]/[C:26]([OH:28])=[O:27].[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([C:2]2[C:3]3[C:4](=[CH:13][S:14][CH:15]=3)[S:5][C:6]3[CH:12]=[CH:11][CH:10]=[CH:9][C:7]=3[N:8]=2)[CH2:19][CH2:18]1

Participants

5

Reactant 3

HCID 531671-MethylpiperazineHCID 5460307FumarateHCID 2131597910-Chloro-thieno[3,4-b][1,5]benzothiazepine

Product 1

HCID 12703434HCID 12703434, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

10-Chloro-thieno[3,4-b][1,5]benzothiazepine (Example 14) is reacted with N-methylpiperazine in toluene giving the base compound, which is then converted to the fumarate, m.p. 186°-188° C.

Sources & evidence

ORD record
ord-b7d73932be404695805fe1b42f1f3903
Source dataset
uspto-grants-1979_03
Patent number
US04144235

Reaction notes

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