Methyl isothiocyanate → HCID 20377482, compound

HRID 614234Notes

Reaction equation

HRID 614234 reaction equation
[CH3:1][N:2]=[C:3]=[S:4].[CH2:5]([O:7][C:8]([CH2:10][O:11][CH2:12][C:13]([NH:15][NH2:16])=[O:14])=[O:9])[CH3:6]>O1CCCC1>[CH3:1][NH:2][C:3]([NH:16][NH:15][C:13]([CH2:12][O:11][CH2:10][C:8]([O:7][CH2:5][CH3:6])=[O:9])=[O:14])=[S:4]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 20377449HCID 20377449, compound

Product 1

HCID 20377482HCID 20377482, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of methyl isothiocyanate (3.52 g.) in dry tetrahydrofuran (20 ml.) was added during the course of 30 minutes to a suspension of ethoxycarbonylmethoxyacetohydrazide (8.50 g.) in absolute alcohol (50 ml.), and the resulting mixture was stirred for a further period of two hours. The solution was then filtered and the clear filtrate evaporated in vacuo. Trituration of the residue with dry diethyl ether then gave the compound CH3NHCSNHNHCOCH2OCH2COOEt as a white solid material (yield, 8.0 g.).

Workup

  1. filtrationThe solution was then filtered
  2. customthe clear filtrate evaporated in vacuo
  3. customTrituration of the residue with dry diethyl ether then gave

Sources & evidence

ORD record
ord-84b0d868e9754fbcb171ccd8635c54f8
Source dataset
uspto-grants-1979_03
Patent number
US04144240

Reaction notes

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