反应详情

Sodium hydroxide (0.4 g., 0.01 mole) and 1-oxamoyl-4-(p-methoxybenzyl)-3-thiosemicarbazide (2.82 g., 0.01 mole) were heated in water (20 ml.) on a steam bath for a period of two hours. The clear solution was then cooled and acidified with dilute hydrochloric acid. The resulting solid was filtered and subsequently dried in vacuo at 50° C. to afford 3-carbamoyl-4-(p-methoxybenzyl)-1,2,4-triazole-5-thiol (2.5 g., 94% yield), m.p. 210°-242° C. The analytical sample melted at 243°-245° C. after being crystallized from a mixture of dimethylformamide and diethyl ether.

1. temperatureThe clear solution was then cooled
2. filtrationThe resulting solid was filtered
3. customsubsequently dried in vacuo at 50° C.