Hydrochloric Acid → HCID 178490897, compound

HRID 614238Notes

Reaction equation

HRID 614238 reaction equation
[OH-].[Na+].[C:3]([NH:8][NH:9][C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[S:11])(=O)[C:4]([NH2:6])=[O:5].Cl>O>[C:4]([C:3]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[C:10]([SH:11])=[N:9][N:8]=1)(=[O:5])[NH2:6]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 20377474HCID 20377474, compound

Product 1

HCID 178490897HCID 178490897, compoundYield 94.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium hydroxide (0.4 g., 0.01 mole) and 1-oxamoyl-4-(p-methoxybenzyl)-3-thiosemicarbazide (2.82 g., 0.01 mole) were heated in water (20 ml.) on a steam bath for a period of two hours. The clear solution was then cooled and acidified with dilute hydrochloric acid. The resulting solid was filtered and subsequently dried in vacuo at 50° C. to afford 3-carbamoyl-4-(p-methoxybenzyl)-1,2,4-triazole-5-thiol (2.5 g., 94% yield), m.p. 210°-242° C. The analytical sample melted at 243°-245° C. after being crystallized from a mixture of dimethylformamide and diethyl ether.

Workup

  1. temperatureThe clear solution was then cooled
  2. filtrationThe resulting solid was filtered
  3. customsubsequently dried in vacuo at 50° C.

Sources & evidence

ORD record
ord-fbe322ff94914fa1b818878843bfeff4
Source dataset
uspto-grants-1979_03
Patent number
US04144240

Reaction notes

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